Louis as well as the judge in Russ Faria’s first trial, who refused to allow any evidence of Hupp’s insurance windfall, despite a mountain of legal precedent to the contrary. Co-authored by veteran true-crime author Charles Bosworth Jr., the book chronicles Schwartz’s frustration with members of Major Case Squad of Greater St. In his book “Bone Deep: Untangling the Betsy Faria Murder Case,” Schwartz details his attempt to exonerate Russ Faria and bring attention to Hupp. It would take Hupp being implicated in two more deaths - one in which she was also the insurance beneficiary - for her to be arrested. And then, prosecutors now say, she killed Betsy and clumsily framed Betsy’s husband. A suburban mom with frumpy clothes and a reputation as the neighborhood “buttinski,” Hupp got herself named the beneficiary on one of Betsy Faria’s life insurance policies. Instead, Schwartz’s involvement with Russ Faria and the murder of his wife, Betsy, has been a constant in his life for a decade - and that’s thanks to Pam Hupp. To date, about 40 syndromes have been shown to have unique epi-signatures may elucidate insights into potential treatment modalities.Kensington Books Russ Faria and his wife, Betsy, enjoy a "celebration of life" cruise a few weeks before her murder. ![]() This research endeavor has resulted in the blossoming of a new area of molecular diagnosis. Bekim Sadikovic (London Health Sciences Centre, Ontario), began exploring the possibility that neurodevelopmental disorders may have unique methylation profiles (epi-signatures) as many causative genes were involved with the epigenetic machinery (histone modification, DNA methylation, chromatin remodeling). The enhancers, named exonic enhancers (eExons) regulate two genes involved in limb development, DLX5 and DLX6, which are 900 kb proximal to DYNC1I1 and the identification of eExons added another level of complexity to genetics ![]() ![]() In collaboration with a group at UCSF, in 2012, novel enhancers embedded in an exon of one gene, DYNC1I1, in the SHFM1 region in chromosome 7q21 was identified. Schwartz’s group identified a complex, chromosomal rearrangement in 10q24 that results in a small tandem duplication in SHFM3 patients. With respect to birth defects, a project was undertaken to identify genes responsible for ectrodactyly (split-hand/split-foot, SHFM). The purpose of the Polyamigos is to explore avenues for treatment of SRS. Schwartz was instrumental in bringing together a group of researchers, with various backgrounds and an interest in polyamine biosynthesis, to form a group named the ‘Polyamigos’. This gene converts spermidine to spermine, and affected males have an abnormally high ratio of these polyamines in their white cells. Schwartz’s group identified mutations in the spermine synthase gene (SMS) which are associated with Snyder-Robinson syndrome. Linkage was achieved in 72 of the families and 36 XLID genes were cloned, many in collaboration with groups spread throughout the world. Roger Stevenson, a senior clinical geneticist at GGC. Over 700 families were enrolled in the project, in collaboration with Dr. For the former, his laboratory concentrated on identifying genes responsible for X-linked intellectual disabilities (XLID). Schwartz’s research interests focused on the causes of intellectual disabilities and birth defects. From 1985 until his retirement in May 2019, Dr. Schwartz is an Emeritus Senior Research Scientist of the Greenwood Genetic Center (Greenwood, SC) and Chair, Medical and Scientific Advisory Board of the Snyder-Robinson Foundation.
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